Biomarkers in Combination with Other Prognostic and Predictive Factors –Individualized Multivariate Statistical Models for Risk and Probability Estimation in Oncology.Implementation into sof
Authors
Pecen, L.; Topolčan, O.; Novák, J.; Jiřina, M.
Year
2020
Published
Biomedical Journal of Scientific & Technical Research. 2020, 28(4), 21762-21765. ISSN 2574-1241.
Type
Article
Departments
Annotation
Each patient has his/her own individual characteristics. It is given by his/her main diagnosis and its detailed description (e.g., in oncology by TNM classification, grading, histological type etc.), comorbidities, results of genetic markers, biomarkers and many other factors. Standard patient care is usually based on the results of large clinical trials. This approach ignores the patient’s individuality. Using patient profiling based on tumor characteristics, genetic markers and biomarkers, it is possible to identify the drug with the highest clinical benefit for small patient groups where, according to the guidelines, treatment choice is no longer defined only by diagnosis and TNM classification. This procedure belongs to the area of personalized medicine. An important methodology is how to find similar patients to a newcomer and how to evaluate clinical benefits and risks of different types of therapies in this group of similar patients. The main focus is on overall survival, but time to progression and adverse reactions to treatment are also important. Based on extensive patient data available in electronic medical records (hospital information systems), similar cases to a newcomer can be identified and some statistics for these similar patients can be provided.